Next, using the DIANA-mirPath program, we investigated the mechanism by which miR-214/199a/199a* activates hepatitis B signaling, pathways in cancer and cell cycle, and found that 3 central cell-cycle promoting genes, E2F2, CDK3 and CDK6 was strikingly enriched in these predicted targets pathway. This evidence concerns the gene CDK6 and hepatitis B virus infection.