Next, using the DIANA-mirPath program, we investigated the mechanism by which miR-214/199a/199a* activates hepatitis B signaling, pathways in cancer and cell cycle, and found that 3 central cell-cycle promoting genes, E2F2, CDK3 and CDK6 was strikingly enriched in these predicted targets pathway. Here, E2F2 is linked to hepatitis B virus infection.