BRAF and melanoma: Among the 35 patients with concordantly BRAF-positive samples, 26 patients had a BRAFV600E (c.1799T > A) mutation in both the primary melanoma and consecutive metastases, eight patients had BRAF V600K (c.1798_1799GT > AA) mutations (eight primary melanomas, four lymph node metastases, and four skin metastases), and one patient had a BRAFV600E (c.1799_1800TG > AA) mutation (in the primary melanoma and matched skin metastasis) (Table 1).