Since the approval of vemurafenib by the Food and Drug Administration (FDA) of the United States in 2011 for treatment of unresectable or metastatic melanomas with a BRAF p.V600E mutation, clinical detection of the BRAF p.V600E mutation has become the standard of care for patients with metastatic melanoma in order to predict response to vemurafenib, dabrafenib and trametinib [4–7]. Here, BRAF is linked to metastatic melanoma.