An NSCLC specimen showed an additional KRAS p.V8I (c.22G > A) mutation in the same allele of p.G13D (c.38G > A) mutation (case P10) and a melanoma specimen showed an addition PIK3CA p.P75S (c.169C > T) mutation (case P8). Here, PIK3CA is linked to non-small cell lung carcinoma.