BRAF and metastatic melanoma: The selective inhibitors of BRAF codon 600 mutants, vemurafenib and dabrafenib, have been shown to improve progression-free and overall survival in metastatic melanoma patients, with either the p.V600E mutation or non-p.V600E mutations at codon 600, such as p.V600K and p.V600R [4, 27–29].