BRAF mutations accompanied by a PIK3CA mutation were observed in 2 of 33 (6.1 %) BRAF-mutated lung cancers, 4 of 34 (12 %) BRAF-mutated CRCs, and 2 of 67 (3.0 %) BRAF-mutated melanomas (Table 4). Here, BRAF is linked to lung cancer.