BRAF and melanoma: BRAF mutations were detected in 33 of 510 (6.5 %) NSCLCs, 34 of 275 (12 %) CRCs, and 67 of 152 (44 %) melanomas, including a melanoma specimen with both p.V600E (c.1799 T > A) mutation and p.S605I (c.1814G > T) occurring in the same allele (Table 2).