Interestingly, FACS analysis revealed that the ALDH− cells were in part transformed to ALDH+ ones by Sh-lnc-p21-infection (Figure 2B), while these changes were not observed in Sh-GFP-infected cells, implying that loss of lincRNA-p21 may induce de-differentiation of ALDH− cells to generate ALDH+ CSCs. Here, LDHA is linked to infection.