In our study, IGF-1R-inhibited melanoma cells showed enhanced TMZ-induced apoptosis, relatively minor at 24–48 hr, more substantial 72 hr post-TMZ in vitro, and much more striking in melanoma xenografts after 5 days of TMZ and 3 days of OSI-906 (Figure 5B, 5C). Here, IGF1R is linked to melanoma.