The most sensitive cell lines (501mel, A375, A375M; Table 1) harbor V600E BRAF; supporting activity in the context of activating RAS-RAF mutations, a study of synthetic lethal interactions identified IGF-1R as a key driver of AKT phosphorylation in KRAS mutant NSCLC [32]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.