ABCA4 and neoplasm: Experimental evidence has suggested different mechanisms by which tumor cells can develop resistance to taxanes, including excluding taxane from cells by ATP-binding cassette transporters, the expression of certain tubulin isoforms and microtubule associated proteins, tubulin gene mutations, alterations in survival or mitotic check point signaling, and methylation-associated Has-miR-9 deregulation [17, 18].