Finally, to determine if Piezo2-dependent mechanisms in the skin contribute to an endothelial cell dependent preclinical pain syndrome, we evaluated the effect of the peripheral administration of ODNs antisense to Piezo2 mRNA in a preclinical model of a cancer chemotherapy-induced painful peripheral neuropathy, induced by oxaliplatin, which we found in preliminary experiments to be endothelial cell dependent. Here, PIEZO2 is linked to peripheral neuropathy.