miR-135 and miR-142 inhibit the adenomatous polyposis coli (APC) expression to enhance the Wnt/β-catenin signaling and tumor cell proliferation and migration [23, 29] while miR-200a, miR-203, miR-214, miR-1826, miR-320 and others attenuate the Wnt/β-catenin signaling by targeting β-catenin to inhibit tumor cell proliferation and migration [30–36]. Here, APC is linked to neoplasm.