In addition, it was recently shown that PUF60 is part of a long non-coding RNA (lncRNA)-associated ribonucleoprotein (RNP) complex, which regulates breast cancer metastasis through modulation of a translational regulatory lncRNA (treRNA), which suppresses the translation of E-cadherin (CDH1) mRNA [27]. Here, PUF60 is linked to breast carcinoma.