Of note, a single miRNA can regulate a multitude of target genes concomitantly; for instance, it has been reported that miR-139-5p suppresses progression of liver cancer by down-regulating Rho-kinase 2 [32]; and miR-139-5p could repress the activity of RAP1B [33] and IGF-IR [34] in colon cancer. This evidence concerns the gene ROCK2 and liver cancer.