We also investigated the role of miR-139-5p on expression of MMP-9 and MMP-7, which all play a key role on tumor metastasis, and results indicated miR-139-5p inhibited the mRNA expression of MMP-9 and MMP-7 both in A549 and SK-MES-1 cells (Figure 4M and 4N). Here, MMP9 is linked to neoplasm.