CYP3A4 and rhabdomyolysis: Study on the spontaneous adverse event reports, using the US Food and Drug Administration Adverse Event Reporting System database showed a six fold increase in the adverse event reporting rate and ratio (AERR) of rhabdomyolysis in concomitant use of simvastatin with CYP3A4 inhibitors compared to simvastatin without CYP3A4 inhibitors (56 events in 14,575,000 prescriptions versus 62 events in 103,822,000 prescriptions) [15].