FKA selectively induces G1 arrest in p53 wild-type bladder cancer RT4 cells via increasing p21/Waf1 and p27/Kip1 expression and G2M arrest in p53 mutant bladder cancer cell lines (i.e. T24, UMUC3, TCCSUP, 5637, HT1376, and HT1197) through down-regulation of Myt1 and Wee1 and activation of CDK1 [22]. This evidence concerns the gene TP53 and urinary bladder carcinoma.