Recently, we and others have demonstrated that FKA exerted potent anti-cancer and anti-carcinogenic activity in a variety of cell culture systems and animal models by induction of the mitochondria mediated apoptosis in cancer cells via up-regulation of pro-apoptotic proteins Bax and death receptor-5 (DR5) and down-regulation of anti-apoptotic proteins (i.e. survivin and XIAP) [19-22]. Here, BIRC5 is linked to cancer.