Since Skp2 overexpression is frequently observed in many cancers and associated with poor prognosis [2, 4], as well as play a critical role in tumorigenesis, cell cycle regulation, metastasis and metabolism [10-15], further elucidation in the novel mechanism of Skp2 degradation that are independent of the Cdh1/APC/C complex may open a new avenue for designing cancer-specific prevention and therapy. The gene discussed is SKP2; the disease is cancer.