IL-32 is considered pro-inflammatory because it induces other pro-inflammatory cytokines and chemokines such as TNF-α, IL-1β, IL-6 and IL-8 by activation of NF-κB and p38 MAPK and because elevated levels of IL32 were notable in synovial tissues of patients with rheumatoid arthritis where those levels correspond to the severity of diseases [5, 9, 12]. This evidence concerns the gene IL32 and rheumatoid arthritis.