In the present study, we utilized DIANA-mirPath to demonstrate that Neurotrophin signaling pathway, mTOR signaling pathway, Ubiquitin mediated proteolysis, Long-term potentiation, Axon guidance, Cholinergic synapse, Gap junction, Dopaminergic synapse, Glutamatergic synapse were the most prominent pathways enriched in quantiles with differential exosomal miRNA patterns related to development of PD and AD. The gene discussed is BDNF; the disease is Alzheimer disease.