TP53 and Alzheimer disease: Among them, Taurine and hypotaurine metabolism (p = 0.0076), B cell receptor signaling pathway (p = 0.0076), Neurotrophin signaling pathway (p = 0.0172), VEGF signaling pathway (p = 0.0182), p53 signaling pathway (p = 0.0351), Adipocytokine signaling pathway (p = 0.0355) were the most prominent pathways enriched in quantiles with differential exosomal miRNA patterns in AD (Table S2), suggesting that these biologic pathways were dysregulated by miRNAs and further involved in development of AD.