Using Western blotting, we observed that ATAD2 siRNA activated the p53-Bcl-2 family proteins in HepG2 cells with wild-type p53, but not in other HCC cells (Hep3B, Huh7, PLC/PRF/5) with mutant p53 (Figure 4C). Here, ATAD2 is linked to hepatocellular carcinoma.