A recent study by O'Leay et al. showed that TLR/NOX1 redox signaling axis accelerate colon cancer cell adhesion, thus increasing metastatic potential of the colon cancer cells [44] Similarly, NOX1-derived ROS generation had impact on TLR4 signaling to enhance tumor metastasis of non-small cell lung cancer (NSCLC) [45]. Here, TLR4 is linked to colonic neoplasm.