APOE and atherosclerosis: Furthermore, we focused on a group of genes affecting metabolic processes, including genes of apolipoprotein E (APOE), vitamin D receptor (VDR), vitamin D binding protein (GC), and two genes of the low density lipoprotein receptor family, low density lipoprotein receptor related protein 1 (LRP1) and low density lipoprotein receptor (LDLR) which may be involved not only in atherosclerosis but also in inflammation and may influence proliferation and migration of vascular smooth muscle cells (VSMCs), key players in the development of ISR [6–11].