FLT3 and acute myeloid leukemia: Similar effects were also observed in primary AML samples (n = 2, Fig. 2b) when treated for 6 h with SKLB-677, although the dose required for the different FLT3-ITD positive patient samples varied substantially, suggesting that other factors influence drug uptake/efflux or activity (Fig. 2b, e.g. patient 1 responded at 1000 nM, patient 3 showed a response at the much lower dose of 10 nM).