For spleens from tumor bearing old mice majority of the upstream regulators are either interferons (IFNγ, IFNα, IRF3, IRF7, and IFNA2) or are related to the immune system (IKBKB, CHUK, NFκB, NFκBIA, STAT3, and mir-21) (Fig. 4 and Supplemental Table 5) and are predicted to be up-regulated. This evidence concerns the gene STAT3 and neoplasm.