LGALS3 and neoplasm: As stated earlier for aged hosts without tumor burden, we observe a decrease in functions related to lymphocytes and leukocytes and the four key factors (C1QA [33, 34], LGALS3 [35], SFRP1 [36], and CCL5 [26]) that do not provide a collective activation of the immune system needed to suppress tumor growth as is commonly accepted in aged hosts.