The combination of GRP94, FN14 and TRAF2 expression, and the absence of Inhibin in breast carcinomas, referred to as the endoplasmic reticulum stress resistance phenotype (ERSRP), was the best signature for discriminating between breast carcinomas according to their BrM progression, regardless of whether or not they expressed ErbB-2 [24]. The gene discussed is TNFRSF12A; the disease is breast carcinoma.