In addition, to avoid BBB permeability maintaining the stromal and phenotypic characteristic of brain metastasis tissue, we treated a group of mice with a subcutaneously engrafted brain metastasis biopsy, which expressed both GRP94 and FN14 proteins, obtained from a woman with primary lung carcinoma that metastasized in the brain. The gene discussed is TNFRSF12A; the disease is lung carcinoma.