Therefore, the overall objective of this review is to assess the available evidence for the temporary discontinuation of diuretics, ACE inhibitors, angiotensin receptor blockers, direct renin inhibitors, non-steroidal anti-inflammatories, metformin and sulfonylureas in adults in primary and secondary care at risk of AKI or with newly diagnosed AKI as a result of an intercurrent illness or a radiological/surgical procedure (planned or unplanned). This evidence concerns the gene REN and acute kidney injury.