Diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, direct renin inhibitors, NSAIDs, metformin and sulfonylureas in at-risk patients experiencing an intercurrent illness are extremely commonly prescribed, and expert consensus (subsequently incorporated into clinical guidelines) recommends the discontinuation of these medications for individuals at risk of AKI during an intercurrent illness. The gene discussed is REN; the disease is acute kidney injury.