To assess whether overexpression of miR-124 or miR-506 leads to the re-expression of hypermethylated and silenced genes in CRC, we measured the mRNA and protein levels of E-cadherin, MGMT and P16 in SW480 and SW420 cells by qRT-PCR and western blotting after transfection with miR-124, miR-506 or scrambled control. Here, MGMT is linked to colorectal carcinoma.