Still, the CYP2E1 mediated joint effect of alcohol- and oleate-induced steatosis on autophagy indicate that the manipulation of CYP2E1 may be a double-edged sword and warrant the exercise of caution in the pharmacological use of CYP2E1 inhibitors for the treatment of alcoholic liver disease in obese individuals. The gene discussed is CYP2E1; the disease is steatosis.