A phase I/II multicenter clinical trial on the use of an EZH2 inhibitor as monotherapy (E7438 or Tazemetostat) in patients with B-cell lymphoma (GCB and non-GCB DLBCL and grade 3 FL) or with advanced solid cancers is currently ongoing (NCT01897571). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.