For instance, in DLBCL harboring EZH2 gain-of-function mutations, the cytotoxic and cytostatic effects induced by a histone deacetylase 1/2 (HDAC1/2) inhibitor were correlated with increased H3K27ac at genes involved in the DNA damage response or apoptosis. This evidence concerns the gene HDAC1 and diffuse large B-cell lymphoma.