Recurrent heterozygous mutations that target specifically Y641 in the SET catalytic domain within the S-adenosylmethionine (SAM) pocket of EZH2 were described in germinal center B-cell diffuse large B-cell lymphoma (GCB DLBCL) and in FL and are found in 22% of patients [17]. Here, EZH2 is linked to diffuse large B-cell lymphoma.