EGFR and non-small cell lung carcinoma: Reversible small-molecule epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), including gefitinib (Iressa) and erlotinib (Tarceva), display dramatic therapeutic efficacy in NSCLC patients that have EGFR-activating mutations, and are recommended as the standard first-line therapy in NSCLC [1, 2].