In conclusion, our study revealed that overexpressed EBV-miR-BART10-3p could promote invasion and migration of NPC cells, through inhibition of its target BTRC expression, thereby inhibiting the ubiquitination of βTrCP downstream substrates β-catenin and Snail, leading to the regulation of many EMT related molecules, such as downregulated expression of E-cadherin, tight junction protein ZO-1 and Claudin-1, as well as upregulated E-box binding zinc finger protein ZEB1 and N-cadherin (Figure 8). This evidence concerns the gene ZEB1 and nasopharyngeal carcinoma.