Our previous microarray data showed that a decrease in BTRC expression was found in NPC samples [25, 26], suggesting that EBV miRNAs might regulate NPC development through its host gene BTRC. However, the mechanism by which EBV miRNAs regulate BTRC expression and the biological function of BTRC in NPC is still largely unknown at present. Here, BTRC is linked to nasopharyngeal carcinoma.