These observations are in line with previous reports, where both MAPK and AKT are required for maintaining proliferation but specific suppression of AKT signaling completely abolishes the tumorigenic capacity of MM cells [42], while MAPK possesses a dual role of promoting proliferation on one side and enhancing anti-proliferative feedback on the other side [11, 33, 43]. This evidence concerns the gene AKT1 and Miyoshi myopathy.