HSPA5 and colonic neoplasm: As shown in Fig. 5e, although both Atg5 and BiP silencing, respectively, increased apoptosis in colon cancer cells harboring the wild type p53 gene (i.e., HCT116 and SW48 cells), Atg5 silencing alone did not show an apoptotic effect in colon cancer cells mutant for the p53 gene (i.e., DLD1 and SW837 cells).