SAMHD1 and infection: In the study presented here, we have explored whether conditions that favor the efficient infection of primary human monocyte-derived dendritic cells (DCs) by either directly removing SAMHD1 (via SIVMAC Vpx), or by counteracting its action on dNTPs (via dNs supplementation) could modulate the extent of vDNA cytidine deamination from the pool of A3 molecules present in target cells following HIV-1 or SIVMAC infection.