SAMHD1 and infection: SAMHD1 is a major block to DCs infection and despite the fact that the mechanism/s of restriction remain debated [5,16,17,18,19,20] and [21,22,23,24], most studies agree on the fact that SAMHD1 is responsible for the low intracellular concentrations of dNTPs and that this situation can be reversed upon supplementation of Vpx or dNs [5,16,17,18,19,20].