SAMHD1 and infection: As well documented in the literature, VLPs-Vpx and dNs exert a positive effect during the infection of DCs: the former by directly forcing SAMHD1 degradation [6,7,14], while the latter by increasing the intracellular levels of dNTPs and therefore by overcoming the dNTPs triphosphohydrolysis antiviral activity of SAMHD1 [5,16,17,18].