Several GWAS studies have identified new susceptibility loci for POAG in ATP-binding cassette, sub-family A (ABCA1), actin filament associated protein 1 (AFAP1), GDP-mannose 4,6-dehydratase (GMDS) [63], phosphomannomutase 2 (PMM2) [64], fibronectin type III domain containing 3B (FNDC3B), rs747782 [65], SIX homeobox 6 (SIX6) [66], transmembrane and coiled-coil domains 1 (TMCO1) and CDKN2B antisense RNA 1 (CDKN2B-AS1) [29], and some of these genes are associated with mitochondrial function. The gene discussed is AFAP1; the disease is open-angle glaucoma.