Analysis of POAG families with a Mendelian inheritance pattern has identified mutations in multiple loci of Optineurin (OPTN) [59], Myocilin (MYOC) [60,61] and WD repeat domain 36 (WDR36) [61] and copy number variation in Tank-binding kinase 1 (TBK1) [62]. The gene discussed is TBK1; the disease is open-angle glaucoma.