In the esophageal squamous-cell carcinoma susceptibility region tagged by rs2239815 [78], we identified an MRE-SNP within the 3' UTR of CCDC117. This LD block contains two apparent candidate genes for cancer susceptibility (XBP1 and CHEK2) (Fig 4D). This evidence concerns the gene CHEK2 and esophageal squamous cell carcinoma.