The second gene containing both a GWAS hit and an MRE-SNP in this study is N4BP1. rs6500395, which is located in the first intron of N4BP1, has been associated with the response of rheumatoid arthritis patients to tocilizumab treatment [76], but this gene also contains an AGO-CLIP-supported C-type MRE-SNP proxy (rs1224) for miR-330-3p in its 3' UTR (Fig 4C). This evidence concerns the gene FBXW7 and rheumatoid arthritis.