POC1A and Severe short stature: The Poc1acha/cha mouse has provided information on the molecular mechanism underlying clinical features of human patients, and highlights male fertility as a potential area of interest for clinicians examining adult male patients with mutations in Poc1a. The Poc1acha/cha and Poc1atm1(KOMP)Mpb mice are valuable tools for studying the molecular mechanisms of dwarfisms and for testing therapeutic interventions.