There are several case reports of IMT being successfully treated with NSAIDs.20–22 According to Applebaum et al,23 because IMTs are composed of organized vasculature and inflammatory tissue admixed with myfibroblasts, and the identification of a substantial presence of vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (Cox-2) enzyme in IMTs, they hypothesized that NSAIDs can be applied to these masses to disrupt the angiogenesis, specifically by interfering with VEGF signaling via Cox-2 inhibition. Here, PTGS2 is linked to inflammatory myofibroblastic tumor.