Fibrinogen synthesized by hepatocytes has been shown to play a key role in the coagulation cascade.20 Previous studies reported that fibrinogen enhanced tumor proliferation and migration in patients with malignancies.21,22 On the other hand, Yamaguchi et al23 showed that interleukin-6 produced by cancer cells stimulated the secretion of fibrinogen in patients with lung cancer. Here, IL6 is linked to neoplasm.