The systemic inflammatory response has been shown to influence tumor development via multifactorial activities, such as those of vascular endothelial growth factor, interleukin-1, and interleukin-6.25,26 Furthermore, the systemic inflammatory response involves an imbalance in the NLR in circulating blood cells.27 The NLR has recently been attracting attention as a prominent blood marker that reflects systemic inflammation. Here, VEGFA is linked to neoplasm.