Although, our previous research indicated that in early phase of acute coronary syndrome (ACS), elderly patients had low levels of TFPI-2 protein and high levels of tissue factor and MMP-1, implying that the lack of TFPI-2 may be related to ACS.18 However, it is still unknown whether TFPI-2 gene polymorphisms could substantially influence the risk of atherosclerosis or not. The gene discussed is TFPI2; the disease is atherosclerosis.