In addition, we noticed that 31.4% of patients with CD were negative for all of the 3 antibodies (ASCA, anti-PAB, and anti-GP2 antibodies), indicating other biomarkers, such as anti-CUZD1 or anti-MZGP2 antibodies,24,25 might be helpful in CD diagnosis. This evidence concerns the gene GP2 and Cowden disease.