One study reported that the HOMA-measured insulin resistance were reduced by 50% in the myo-inositol treated patients,11 and a previous study in patients with polycystic ovary syndrome reported similar results.28 The researchers believed that this reduction in insulin resistance was predominantly attributable to the adipocytokine adiponectin, because it was the only adipocyte-derived hormone downregulated in insulin-resistant patients.11 This evidence concerns the gene INS and Insulin resistance.