ADIPOQ and obesity due to melanocortin 4 receptor deficiency: For example, Gu et al reported a different association of ADIPOQ genetic variants, which is an important molecular mechanism responsible for the link between obesity and PCa, and with PCa risks in the normal weight and overweight subgroups.19 Lifestyle intervention can reduce the risk of diabetes progression by ≥50% in high-risk individuals.20 In our results, the identified interaction between BMI and GRS suggests that environmental factors associated with obesity may modify inherited risk factors.