Hypoglycemia not associated with diabetes and/or its therapy is an uncommon clinical disorder, and tumor-induced hypoglycemia (TIH) caused by different mechanisms is a rare clinical entity.7–9 TIH usually appears as a result of insulin hypersecretion by pancreatic islet β-cell tumor (insulinoma), and can also be developed by other nonpancreatic tumors (NICTH).9 The serum glycemia, insulin, C-peptide levels could be used for the diagnosis of insulinoma, and the serum GH, IGF-I, IGFBP3, and IGF-II, especially big IGF-II levels could be used for the diagnosis of NICTH.3,7–10. The gene discussed is INS; the disease is Hypoglycemia.