MTOR and Autoimmunity: As such, deregulation of mTOR can facilitate T-dependent autoimmune disorders like systemic lupus erythematosus (Koga et al., 2014; Fernandez et al., 2006; Kato and Perl, 2014) and multiple sclerosis (Delgoffe et al., 2011; Esposito et al., 2010).