The significant association for EN3 was located in the intron 18 of KIAA1549 gene on GGA1, which has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma in human (http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIAA1549) [44]. This evidence concerns the gene GGA1 and pilocytic astrocytoma.