HIF1A and breast carcinoma: In line with recent studies from our group [15, 44] that elucidated that interference of Archazolid with the iron metabolism leads to S-phase cell cycle arrest in breast cancer, Archazolid A stabilized Hif1α in leukemic cells (Figure 9A-9C) which was abrogated by simultaneous treatment with iron citrate (Figure 9C).