MSH6 and colorectal carcinoma: In our series, 42.5% of patients presented at least one Bethesda criterion, 24.7% patients had at least one MMR gene deficiency in CRC tissue (mostly MLH1 deficiencies, but also MSH2, PSM2 and MSH6 deficiency in a different degree of combination) and 10.8% had both at least one positive Bethesda criterion and a MMR gene deficiency.