Previous research on the concentric hypertrophy pathway demonstrated that mitogen-activated protein kinase (MEK1/2) activated ERK1/2 and c-Jun N-terminal kinase (JNK), which induced calcineurin expression and promoted the transcription factor nuclear factor of activated T-cells, cytoplasmic 3 (NFATc3) into the nucleus [17] and translocated downstream gene b-type natraretic peptide (BNP), the levels of BNP which is a risk for heart disease [18]. The gene discussed is NPPB; the disease is heart disorder.