siRNA-based knockdown of TRPM4 significantly reduced the current size in LNCaP (Figure 4D; IV are shown in Supplementary Figure 3A) and DU145 (Figure 4E; IV are shown in Supplementary Figure 3B), and reduced current size in PC3 (Figure 4F; IV are shown in Supplementary Figure 3C) demonstrating the TRPM4-specificity of the detected currents in prostate cancer cells. The gene discussed is TRPM4; the disease is prostate carcinoma.