Whereas in hPEC TRPM4 exhibited currents of 70 ± 13 pA/pF, in the prostate cancer cell lines, the TRPM4 current size was 35 ± 12 pA/pF in LNCaP, 59 ± 17 pA/pF in DU145, 9 ± 5 pA/pF in PC3 cells for 10 μM Ca2+ and 56 ± 11 pA/pF in PC3 cells for 25 μM Ca2+ (Figure 4B). The gene discussed is TRPM4; the disease is Familial prostate cancer.