The CRT-mE6 or CRT-mE6E7L2 vaccine elicited an E6 a.a. 90–99 specific CD8+ cytotoxic effector T cell response similar to that present in C57BL/6 mice after spontaneous regression of MusPV1 papilloma in unvaccinated mice. The gene discussed is CD8A; the disease is papilloma.