Further analysis of these tails for MusPV1 E6/E7 transcript by in situ hybridization revealed strong staining in the papilloma of the mice treated with OT-1 cells after MusPV1 challenge (Fig 6C), whereas the tails of mice treated with adoptive transfer of the MusPV1 E6-specific CD8+ T cell line were devoid of signal, suggestive of viral clearance or profound suppression of early transcription (Fig 6B). The gene discussed is CD8A; the disease is papilloma.