The mode of progression in patients with a positive PET-CT who progressed was anemia (10 patients, including one patient who also developed amyloidosis and one patient with central nervous system disease), bone disease (6 patients, including 2 patients with concurrent renal failure and one with cryoglobulinemia), renal failure (1 patient) and rapid rise in M protein (1 patient). The gene discussed is MYOM2; the disease is anemia.