We chose a TTP of 72 months, which is approximately three times the TTP expected with primary Rd.21 The presentation and distribution of several clinical features in exceptional responders (Table 1) appear to be similar to those seen in MM in general, including gender, hemoglobin concentration, monoclonal protein type, serum M protein concentration and bone marrow involvement.22 The proportion of patients with light-chain MM was also as expected, although overall urine M protein levels was ⩾2 g/dl in one patient and the serum involved free light chain levels were <1000 mg/dl in all patients. This evidence concerns the gene TNFSF14 and Miyoshi myopathy.