Contrary to what was initially believed, the ability to produce IL-10 has been shown not only in Th2 and Treg [107, 108] cells but also in Th1, Th9, Th17, and CD8+ T cells, especially those that are long-lived [107–119], and the occurrence of these multifunctional populations in the context of IL-10 still needs to be correctly determined in human tuberculosis. The gene discussed is IL10; the disease is tuberculosis.