Interestingly, the percent of hormone receptor negative BC remained relatively flat across all age groups in the GCR data (approximately 22-23%), whereas in the US SEER data, the percent of hormone receptor negative cancers went from as high as 33% among women ≤40 years of age down to only 18% among women aged 56 years and older. The gene discussed is NR4A1; the disease is breast cancer.